Statins in women
Do statins work as well as women as in men? A meta-analysis in Archives of Internal Medicine raises the possibility that they may not. Across 11 RCTs in 43,000 patients, statins as secondary prevention were associated with reduced risk of cardiovascular events in both sexes, but reductions in stroke and all-cause mortality were significant only in men. An accompanying Commentary is sceptical, arguing that other analyses have shown benefit to women, and that a better question would be whether the effect sizes are comparable. However, as an Editorial says, this question can only be answered by recruiting more women into trials.
Extract from OnMedica