European Radiology, July 2012; Imaging vascular function for early stage clinical trials …

Imaging vascular function for early stage clinical trials using dynamic contrast-enhanced magnetic resonance imaging
Citation: European Radiology, July 2012, vol./is. 22/7(1451-1464), 0938-7994;1432-1084 (July 2012)
Author(s): Leach M.O.; Morgan B.; Tofts P.S.; Buckley D.L.; Huang W.; Horsfield M.A.; Chenevert T.L.; Collins D.J.; Jackson A.; Lomas D.; Whitcher B.; Clarke L.; Plummer R.; Judson I.; Jones R.; Alonzi R.; Brunner T.; Koh D.M.; Murphy P.; Waterton J.C.; Parker G.; Graves M.J.; Scheenen T.W.J.; Redpath T.W.; Orton M.; Karczmar G.; Huisman H.; Barentsz J.; Padhani A.

Abstract: Many therapeutic approaches to cancer affect the tumour vasculature, either indirectly or as a direct target. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has become an important means of investigating this action, both pre-clinically and in early stage clinical trials. For such trials, it is essential that the measurement process (i.e. image acquisition and analysis) can be performed effectively and with consistency among contributing centres. As the technique continues to develop in order to provide potential improvements in sensitivity and physiological relevance, there is considerable scope for between-centre variation in techniques. A workshop was convened by the Imaging Committee of the Experimental Cancer Medicine Centres (ECMC) to review the current status of DCEMRI and to provide recommendations on how the technique can best be used for early stage trials. This review and the consequent recommendations are summarised here. Key Points Tumour vascular function is key to tumour development and treatment Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can assess tumour vascular function Thus DCE-MRI with pharmacokinetic models can assess novel treatments Many recent developments are advancing the accuracy of and information from DCE-MRI Establishing common methodology across multiple centres is challenging and requires accepted guidelines.

European Society of Radiology 2012.

Publication Type: Journal: Article
Source: EMBASE

Knight, S, et al; Annals of the Rheumatic Diseases, June 2012

The influence of anti-TNF therapy upon incidence of keratinocyte skin cancer in patients with rheumatoid arthritis:    Longitudinal results from the British Society for Rheumatology Biologics Register
Citation: Annals of the Rheumatic Diseases, June 2012, vol./is. 71/6(869-874),
0003-4967;1468-2060 (June 2012)
Author(s): Mercer L.K.; Green A.C.; Galloway J.B.; Davies R.; Lunt M.; Dixon W.G.; Watson K.D.; Symmons D.P.M.; Hyrich K.L.; Maiden N.; Price T.; Hopkinson N.; O’Reilly S.; Hordon L.; Griffiths I.; Porter D.; Capell H.; Hassell A.; Benitha R.; Choy E.; Walsh D.; Emery P.; Knight S.; Bruce I.; Taggart A.; Scott D.; Thompson P.; McCrae F.; Goodfellow R.; Kitas G.; Jubb R.; Abernethy R.; Clarke S.; Green S.; Sanders P.; Coulson A.; Harrison B.; Bukhari M.; Klimiuk P.
Source: EMBASE

Heathcote, JA, Nyholm E; Journal of Family Planning & Reproductive Health Care, 2013

Foundations for the future: preparing tomorrow’s medical educators today

JA Heathcote, E Nyholm – Journal of Family Planning and .., 2013 – jfprhc.bmj.com
Good teachers have a major influence on the quality and safety of medical care delivered to patients. As the area of sexual and reproductive health care (SRH) has evolved there has always been a strong commitment to supporting the development of sexual 

Matytsina-Quinlan L; Journal of Family Planning & Reproductive Health Care 2013

Difficult removal of a deep implant using a traditional removal method

Citation:  Journal of Family Planning & Reproductive Health Care, 01 2013, vol./is. 39/1(64-5), 1471-1893;1471-1893 (2013 Jan)

Author(s):  Matytsina-Quinlan L
Publication type: Journal Article
Source:  Medline
Full-text not immediately available but we can order this article if required.

Common painkillers and kidney failure in children

Journal of Pediatrics

Date published: 28/01/2013 17:18

Summary by: Angela Bennett

A retrospective chart review, being published in the Journal of Paediatrics reports on the number of children diagnosed with acute kidney injury caused by NSAIDs in one U.S hospital over an 11 and a half year span.

Out of 1015 children that presented with acute kidney injury, 27 were identified to have NSAID-associated acute kidney injury (2.7%). Seventy-eight percent of the 27 patients had been using NSAIDs for less than 7 days. None of the patients died or developed permanent kidney failure, but 30% of the children had evidence of mild chronic kidney damage persisting after recovery from the episode of acute kidney injury.

Fit 4 Work 10 Week Diet and Nutrition Programme!

Breakfast Cereal 3Congleton and Macclesfield Courses

  • Expert nutrition and life coaching advice plus fitness training
  • 1 hour session each week for 10 weeks
  • £50 for the full 10 weeks
  • First 30 East Cheshire Trust Staff to enrol receive £20 subsidy– so just £30 to pay!

Congleton Programme

  • Starts Thursday 7th February 2013
  • Sessions every Thursday from 17:30 until 18:30

Macclesfield Programme

  • Starts Tuesday 5th March 2013
  • Sessions every Tuesday from 17:30 until 18:30

Crewe Programme

  • Programme to start March 2013 pending amount of interest received

Click here for further details

If you would like to enrol please contact Alison.nuttall@nhs.net no later than 28th January for the Congleton programme and by 14th February for the Macclesfield programme.

Pilates at Congleton War Memorial and MDGH
Please email your expression of interest for the following classes to: bruna@highpeakpilates.co.uk

If enough interest is received classes would commence beginning of February -at £4 per session

Pilates Class – Tuesday Evenings, Congleton War Memorial, 17.30 until 18.30

Pilates Class – Wednesday Evenings, MDGH, 17.30 until 18.30

Pilates Class – Thursday Lunchtime, MDGH, 12.30 until 13.15

New Staff Health Promotion Activity Calendar

Take a look at our new health promotion calendar to find out more about health awareness activities in your workplace from January until April 2013.

View the Staff Health Promotion Calendar

Your Suggestions

The new Employee Wellbeing Strategy is based on the following three staff pledges which reflect East Cheshire Trusts commitment to employee wellbeing.  The Wellbeing Group meet on a monthly to discuss, develop and review actions against the following staff wellbeing pledges

  • Increase Physical Wellbeing at Work
  • Focus on Weight Management & Healthy Lifestyles
  • Increase Mental Health and Wellbeing at Work

If you have any suggestions or ideas which could help with this work or would like to be become a member of the Wellbeing Steering Group, please contact:

Eileen Platt, Wellbeing Group Chair   Eileen.platt@nhs.net