Moult D.; Chandrasekaran S; Diabetic Medicine, March 2013,

Comparison of multiple daily injections (MDI) vs continuous subcutaneous insulin infusion (CSII) methods of insulin delivery in children with Type 1 diabetes in a small district general hospital

Citation: Diabetic Medicine, March 2013, vol./is. 30/(100-101), 0742-3071 (March 2013)

Author(s): Moult D.; Chandrasekaran S.

Language: English

Abstract: Objective: To compare the efficacies of two different methods of insulin delivery in diabetic children in a small district general hospital, with regard to their average HbA1c, their daily insulin requirements and the results on their body mass index (BMI), the average reported number of non-severe hypoglycaemic events a week, and the rate of both long-term and acute complications in these children.

Methods: Data were collected retrospectively between December 2010 and December 2011. A total of 80 patients were included in this audit (40 MDI vs 40 CSII). The patients were divided into thre e different age groups (below five, five to 12, over 12). Results: The average HbA1c was 8.8% for the MDI group compared with 8.4% for the CSII group. The average daily insulin requirement was 0.81u/kg/day for the MDI group compared with 0.74u/kg /day for the CSII group. The average BMI was  0.6kg/m<sup>2</sup> for the MDI group compared with 19.6kg/m<sup>2</sup> for the CSII group. The number of non-severe hypoglycaemic events was recorded at an average of 0.69 episodes per week for the MDI group compared with 1.84 episodes per week for the CSII group. The difference in HbA1c was most marked in under fives (8.4% vs 7.8%). There were no signs of nephropathy in either group among the over 12s. However, lipid abnormalities in the form of elevated cholesterol was more often seen in the CSII group compared with the MDI group in the over 12s (seven vs five). Conclusions: CSII was found to be the overall better treatment in younger age groups, but loses its effectiveness in over 12 year olds.

Publication Type: Journal: Conference Abstract

Source: EMBASE

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