Archive for the 'Evidence' Category

The safety of antidepressants in pregnancy

Maternal antidepressants are implicated in ADHD, but so is maternal depression

Click for article

The safety of antidepressants in pregnancy is controversial, partly because of profound methodological difficulties in separating the fetal effects of antidepressants from those related to maternal depression (confounding by indication). One central concern is the potential impact of these drugs on fetal brain development. Such effects may be subtle and possibly only detectable years after exposure, such as an increased susceptibility to (multifactorial) neurodevelopmental conditions.

Advertisements

Routine use of beta blockers in MI patients without heart failure is questioned

Click for article

Patients who have had a myocardial infarction (MI) but do not have heart failure or left ventricular systolic dysfunction do not seem to benefit from beta blockers, a large UK study published in the Journal of the American College of Cardiology has found

Anaemia is associated with hearing loss in adults

Iron deficiency anaemia (IDA) has been found to be associated with hearing loss in adults by a study published in JAMA Otolaryngology – Head and Neck Surgery.

Using the electronic medical records of 305 339 adults aged between 21 and 90 years, researchers at Pennsylvania State University College of Medicine examined the association between IDA and sensorineural hearing loss (when there is damage to the cochlea or to the nerve pathways from the inner ear to the brain) and conductive hearing loss (hearing loss because of problems with the bones of the middle ear). IDA was determined by low haemoglobin and ferritin levels for age and sex.

Solanezumab and the amyloid hypothesis for Alzheimer’s disease

Click for article

Click for article

Solanezumab’s failure is a wake-up call to look elsewhere for an answer to dementia

Is the amyloid cascade hypothesis of Alzheimer’s disease too big to fail? It proposes that brain deposition of β amyloid protein is the critical early event in the pathogenesis of Alzheimer’s disease and has been the centrepiece of dementia research for decades. The hypothesis suggests that removing β amyloid will reverse or prevent the clinical expression of dementia. However, in all phase III clinical trials to date, treatments targeting β amyloid have failed to improve cognitive outcomes despite reducing brain β amyloid.

End of life care for infants, children and young people with life limiting conditions: summary of NICE guidance

Click for article

Click for article

Children and young people can have a wide range of life limiting conditions and may sometimes live with such conditions for many years. This guideline recommends that end of life care be managed as a long term process that begins at the time of diagnosis of a life limiting condition and entails planning for the future. Sometimes it may begin before the child’s birth. It is part of the overall care of the child or young person and runs in parallel with other active treatments for the underlying condition itself. Finally, it includes those aspects related to the care of the dying.

Swimming, aerobics, and racquet sports are linked to lowest risk of cardiovascular death

Click for article

Click for article

Swimming, racquet sports, and aerobics seem to be the best forms of exercise for reducing the risk of death from heart disease and stroke, research published in the British Journal of Sports Medicine has found.

The researchers said that the small number of events impaired the statistical power in some analyses. There were relatively few deaths from all causes among runners and football players, which may explain the wide confidence intervals. However, they concluded, “These findings demonstrate that participation in specific sports may have significant benefits for public health.”

The digital patient: transforming primary care?

patientsin_controlA report from the Nuffield Trust, an independent health charity, looks at the evidence available on digital technology and its impact on patients in primary care and the NHS. You can access commentary, background information and the report here

Here’s why we need evidence

evidently-cochrane-logoEveryday nursing requires the appropriate use of evidence and this website  from Evidently Cochrane provides useful insights. The article about pressure ulcers illustrates why evidence is needed for everyday practice.

Evidence can be found from a variety of sources and with busy workloads and winter pressures coming, you may find it is hard to find time to search for reliable evidence.

Don’t worry – we can help you!

Your Library and Knowledge Service has skilled  outreach specialists who can help you, either by running an evidence  search or training you to do it effectively. So get ahead and get in touch with us if you are based at East Cheshire NHS Trust.

Cranberry capsules do not reduce urinary tract infections in older women, study finds

Click for article

Click for article

Taking cranberry capsules did not reduce urinary tract infections (UTIs) in older women living in nursing homes, a US randomised trial has shown.

UTIs are very common among nursing home residents: bacteriuria is detected in 25-50% of women living in nursing homes, and pyuria is present in 90% of these. Cranberry products have been of interest in preventing UTIs in this group of people, to reduce unnecessary use of antibiotics.

Women are unaware of pregnancy risks linked with sodium valproate

Click for article

Click for article

Doctors are being asked to make sure that women and girls with epilepsy know about the risks of taking sodium valproate during pregnancy, after a survey found that half of those questioned were unaware that it could harm the fetus.

The charities Epilepsy Action, Epilepsy Society, and Young Epilepsy conducted a survey earlier this year, in conjunction with the Medicines and Healthcare Products Regulatory Agency (MHRA), of 2788 women aged 16 to 50 with epilepsy.

Overwhelmed by information?

cas-poster

BMJ Infographics

Highlighted resource:

BMJ INFOGRAPHICS

These are great visual summaries of a variety of conditions, their management and treatments, and visual overviews of article recommendations. They are found attached to a variety of articles and editorials, and some of the key infographics are found on the infographics page. For example, the infographic of the NICE sepsis guidance or a visual guide to recognising past congenital heart surgery in adults.

New books

NewBooksThe Library & Knowledge Service purchased a large number of new books last month ~ view a selection of the new titles here.

All members of East Cheshire NHS Trust staff, students on placement and volunteers are able to borrow books from the Library.

Contact the Library for more information: ecn-tr.stafflibrary@nhs.net / 01625 66 1362.

 

Reduction in breast cancer deaths is due to treatment not screening, finds study

Click for article

Click for article

The fall in breast cancer mortality seen after widespread mammography screening was introduced in the US was mainly due to improved systemic therapy and not earlier detection of tumours, a comparison of national cancer data before and after the introduction of screening programmes has shown.

SSRI exposure in pregnancy linked to speech disorders in offspring

Click for article

Click for article

A significant rise in the risk of speech and language disorders was found among children born to mothers prescribed selective serotonin reuptake inhibitors (SSRIs) during pregnancy, a study published in JAMA Psychiatry has found.

NICE calls for tailored care for complex, long term health conditions

Nice_logo   The number of people with many long-term health conditions is set to rise and physicians need to discuss both the benefits and any adverse effects of treatments with patients.

Aimed at healthcare professionals, GPs and physicians, a new NICE guideline (Multimorbidity: clinical assessment and management, NG56) sets out ways to put patients with complex health issues at the heart of decisions about their care, including how to decide between different medicines and treatments. It should also help clinicians to work with their patients to  deliver person centred care suited to their needs.

The news release can be read here and the full guideline is Multimorbidity: clinical assessment and management NICE guideline [NG56]

Burns from e-cigarettes and other electronic nicotine delivery systems

Click for article

Click for article

With increasing use of electronic cigarettes (e-cigarettes) and other electronic nicotine delivery systems (ENDS) globally, the debate surrounding the potential harms or benefits may shift to ensuring that the devices are manufactured, marketed, and sold according to standards that reduce harm and promote health. Burns from overheating or explosions of ENDS are an emerging and under-researched concern. In light of the recent ruling that grants the US Food and Drug Administration authority to regulate ENDS1 and as their use becomes widespread worldwide, a clinical, public health, and regulatory framework to reduce ENDS related burns is needed.

Eggs or peanuts in early infant diet may cut allergy risk

Click for article

Click for article

Introducing eggs or peanuts early into infants’ diet is associated with a lower risk of developing egg or peanut allergy, says a systematic review of the evidence published in JAMA.

The review found “moderate certainty” evidence that introducing eggs to the infant diet at 4 to 6 months was associated with reduced egg allergy and that introducing peanuts at 4 to 11 months was associated with reduced peanut allergy when compared with later introduction of these foods.

NHS winter pressures are becoming an all year reality, warn experts

Click for article

Click for article

The type of intense extra workload pressure often experienced by the NHS in winter has become a year long experience, say experts responding to the publication of the latest official data on the performance of the NHS in England.

NHS England’s combined performance summary data show an NHS that is missing many of its targets and hitting new record lows for performance in some areas.

New books

NewBooks

The Library & Knowledge Service purchased a large number of new books last month ~ view a selection of the new titles here.

All members of East Cheshire NHS Trust staff, students on placement and volunteers are able to borrow books from the Library.

Contact the Library for more information: ecn-tr.stafflibrary@nhs.net / 01625 66 1362.

 

Deaths from heart disease in UK fall, but prevalence is unchanged

Click for article

Click for article

Cardiovascular disease (CVD) mortality in the United Kingdom has decreased significantly over the past 30 years, but its prevalence has shown little change, and major differences exist in the burden of CVD among the four constituent countries and between men and women, a review has found.

Combined HRT may raise breast cancer risk, study finds

Women taking combined hormone replacement therapy (HRT) are 2.7 times more likely to develop breast cancer than non-users, and the risk may increase with longer use, a study published in the British Journal of Cancer has found.

Click for article

Click for article

The researchers, from the Institute of Cancer Research in London, said that previous studies may have substantially underestimated the risk of breast cancer from combined HRT, as they did not update information about a woman’s HRT use or analyse accurately to allow for her age at menopause.

The new research was part of the Breast Cancer Now Generations Study, which is following more than 100 000 women for 40 years to investigate the causes of breast cancer.

Paracetamol is no more likely to exacerbate asthma in children than ibuprofen, shows study

Click for article

Click for article

Using paracetamol to treat fever or pain is no more likely than ibuprofen to exacerbate asthma in children with mild persistent asthma, a randomised trial has shown (in the New England Journal of Medicine).

Observational data have previously linked paracetamol and asthma symptoms to decreased lung function, so some doctors have recommended avoiding the drug in children with asthma. But data from randomised trials have been limited.

Oily fish intake reduces risk of diabetic retinopathy, study shows

Click for article

Click for article

Older patients with type 2 diabetes who consume dietary omega 3 fatty acids equivalent to at least two weekly servings of oily fish have a significantly lower risk of sight threatening diabetic retinopathy than those who eat less, a prospective observational study has shown.1

Diabetic retinopathy is a major cause of vision loss in older people. The pathogenesis is not fully understood, but inflammation, oxidative stress, and microvascular changes play important roles…

internurse

internurse logo

The library currently has a free trial to the internurse and MAHcomplete e-journal collections.

Internurse is the UK’s largest collection of peer-reviewed nursing content, and home of the British Journal of Nursing. Internurse covers primary and secondary care settings as well as the whole spectrum of specialist nursing practice including cardiology, neuroscience, mental health, palliative care and wound care.

Access the collection with your East Cheshire NHS Athens account: Login to Athens. Select ‘MAG Online Library’ from the list of resources.

Internurse guide

If you would like to find out more or have any questions please phone us on 01625 661362 or send us an email.


Links to other pages

Blog Stats

  • 26,665 hits

Enter your email address to follow this blog and receive notifications of new posts by email.

Search by category

Archive of previous posts