Oral antifungal is associated with increased risk of miscarriage

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Use of the oral antifungal drug fluconazole during pregnancy was associated with an increased risk of miscarriage in an analysis of 1.4 million pregnancies in Denmark published in JAMA.

Vaginal candidiasis is common during pregnancy. Although intravaginal formulations of topical azole antifungals are the first line treatment for pregnant women, oral fluconazole is often used in cases of recurrence or severe symptoms or when topical treatment has failed.