This month in Eyes on Evidence
Acid-suppressive drugs and oesophageal adenocarcinoma in Barrett’s oesophagus
A systematic review and meta-analysis indicates that proton pump inhibitors reduce the risk of oesophageal adenocarcinoma and high-grade dysplasia in people with Barrett’s oesophagus.
Prescriptions for anxiolytics and hypnotics and risk of death
A population-based cohort study in UK primary care suggests that people who are prescribed anxiolytic and hypnotic drugs have a significantly increased risk of death from any cause over a 7-year period.
Assessment and treatment of dementia in older adults
A systematic review finds that brief cognitive assessment tools can adequately detect early dementia, but whether interventions for mild cognitive impairment or early dementia have a clinically significant effect is unclear.
Bedtime schedules and children’s cognition and behaviour
Two analyses of 7-year-olds in the UK Millennium Cohort Study suggest that not having a regular bedtime is associated with impaired cognition in girls and behavioural difficulties in both girls and boys.
Trained glycaemia alert dogs for people with type 1 diabetes
A small UK intervention study suggests that trained glycaemia alert dogs may be able to notify people with type 1 diabetes during blood glucose variations.
NICE opens consultation on the NICE Accreditation Process Manual Update
NICE is inviting comments on its proposals to update the NICE Accreditation Process Manual.
NICE has recently published Evidence Updates on:
- Physical activity and the environment
- Autism in adults
- Opioids in palliative care
This article “Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett’s esophagus” was published in Nature Genetics, October 2012, vol./is. 44/10(1131-1136), 1061-4036;1546-1718 (October 2012)
Author(s): Su Z.; Gay L.J.; Strange A.; Palles C.; Band G.; Whiteman D.C.; Lescai F.; Langford C.; Nanji M.; Edkins S.; Van Der Winkel A.; Levine D.; Sasieni P.; Bellenguez C.; Howarth K.; Freeman C.; Trudgill N.; Tucker A.T.; Pirinen M.; Peppelenbosch M.P.; Van Der Laan L.J.W.; Kuipers E.J.; Drenth J.P.H.; Peters W.H.; Reynolds J.V.; Kelleher D.P.; McManus R.; Grabsch H.; Prenen H.; Bisschops R.; Krishnadath K.; Siersema P.D.; Van Baal J.W.P.M.; Middleton M.; Petty R.; Gillies R.; Burch N.; Bhandari P.; Paterson S.;
Edwards C.; Penman I.; Vaidya K.; Ang Y.; Murray I.; Patel P.; Ye W.; Mullins P.; Wu A.H.; Bird N.C.; Dallal H.; Shaheen N.J.; Murray L.J.; Koss K.; Bernstein L.; Romero Y.; Hardie L.J.; Zhang R.; Winter H.; Corley D.A.; Panter S.; Risch H.A.; Reid B.J.; Sargeant I.; Gammon M.D.; Smart H.; Dhar A.; McMurtry H.; Ali H.; Liu G.; Casson A.G.; Chow W.-H.; Rutter M.; Tawil A.; Morris D.; Nwokolo C.; Isaacs P.; Rodgers C.; Ragunath K.; MacDonald C.; Haigh C.; Monk D.; Davies G.; Wajed S.; Johnston D.; Gibbons M.;
Abstract: Barrett’s esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia, and it strongly predisposes to esophageal adenocarcinoma (EAC), a tumor with a very poor prognosis. We report the first genome-wide association study on Barrett’s esophagus, comprising 1,852 UK cases and 5,172 UK controls in the discovery stage and 5,986 cases and 12,825 controls in the replication stage. Variants at two loci were associated with disease risk: chromosome 6p21, rs9257809 (P combined = 4.09 x 10<sup>-9</sup>; odds ratio (OR) = 1.21, 95% confidence interval (CI) =1.13-1.28), within the major histocompatibility complex locus, and chromosome 16q24, rs9936833 (P combined = 2.74 x 10<sup>-10</sup>; OR = 1.14, 95% CI = 1.10-1.19), for which the closest protein-coding gene is FOXF1, which is implicated in esophageal development and structure. We found evidence that many common variants of small effect contribute to genetic susceptibility to Barrett’s esophagus NHS Evidence | library.nhs.uk Page 7 and that SNP alleles predisposing to obesity also increase risk for Barrett’s esophagus.
2012 Nature America, Inc. All rights reserved.
Country of Publication: United States
Publisher: Nature Publishing Group (345 Park Avenue South, New York NY 10010-1707, United States)
Publication Type: Journal: Article