The fall in breast cancer mortality seen after widespread mammography screening was introduced in the US was mainly due to improved systemic therapy and not earlier detection of tumours, a comparison of national cancer data before and after the introduction of screening programmes has shown.
Combined HRT may raise breast cancer risk, study finds
Women taking combined hormone replacement therapy (HRT) are 2.7 times more likely to develop breast cancer than non-users, and the risk may increase with longer use, a study published in the British Journal of Cancer has found.
The researchers, from the Institute of Cancer Research in London, said that previous studies may have substantially underestimated the risk of breast cancer from combined HRT, as they did not update information about a woman’s HRT use or analyse accurately to allow for her age at menopause.
The new research was part of the Breast Cancer Now Generations Study, which is following more than 100 000 women for 40 years to investigate the causes of breast cancer.
NICE recommends dropping two drugs from Cancer Drugs Fund
Two drugs currently provided under the Cancer Drugs Fund (CDF) should cease to be available because they are not cost effective, the National Institute for Health and Care Excellence (NICE) has concluded.
Everolimus for breast cancer (Afinitor, Novartis) and ibrutinib for mantle cell lymphoma (Imbruvica, Janssen) do not meet the grade, says NICE in draft guidance now open for consultation.
Stress is unlikely to increase breast cancer risk, study finds
A large prospective study, published in Breast Cancer Research, has found no association between breast cancer risk and stress levels or adverse life events.1 Women with breast cancer have often attributed their cancer to psychological stress, although the scientific evidence for this has been inconclusive.
The Generations study, set up by Breast Cancer Now, the United Kingdom’s largest breast cancer research charity, included 106 000 women in the UK.
Frozen tissue service offers fertility hope to young people with cancer
Scientists at Edinburgh University have developed a service to store testicular tissue from boys as young as 1 who are at risk of infertility because of cancer treatment. In future boys as well as girls might be able to have their fertility restored subsequent to chemotherapy.
The announcement comes after the birth of the first UK baby to be born after his mother had a transplant of her own, previously frozen, ovary tissue.
Review of Cancer Drugs Funds list leads to changes
The Cancer Drugs Fund (CDF) has today completed a further review of the effectiveness of treatments it funds to ensure it delivers the best outcomes for patients. The fund will no longer pay for 16 medicines used to treat a variety of cancers, including breast prostate and pancreatic cancer.
An update on the list can be found here
BBC Health News also recently reported the changes, read the news item here
The decision summaries can be found on NHS England website
Long term NSAIDs are associated with lower colorectal cancer risk, study shows
Taking low dose aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) continuously in the long term is associated with a lower risk of colorectal cancer, a Danish case-control study has shown.
The study, published in the Annals of Internal Medicine, analysed data on drug use, comorbid conditions, and history of colonoscopy from Danish prescription and patient registries.
NICE Guideline updated to support GP’s and help diagnose cancer faster
NICE has updated and redesigned its guideline to support GP’s in recognising the signs and symptoms of 37 different cancers and to aid faster referral for the right tests.
The guideline focuses on the symptoms that a patient might experience and present with in surgeries. It should enable GP’s to monitor people presenting with less severe symptoms, so that fewer cancers are missed.
NICE hope that the guideline will make its recommendations easier for GP’s to use, speeding up the referral process and make diagnosis quicker.
Find the NICE Guideline: NG12 Suspected Cancer : Recognition and Referral
Read the full story here
Women are four times less likely to have curative surgery if breast cancer is diagnosed as emergency rather than urgent GP referral
Women with breast cancer are four times less likely to have potentially curative surgery if their condition is diagnosed as an emergency rather than through an urgent GP referral, a report from Public Health England and Cancer Research UK has shown.
On a national level the report looked at how treatment varies in different cancers, depending on the patient’s route to diagnosis.
Experts call for tobacco industry to pay for smoking cessation work
The tobacco industry should be forced to pay towards smoking cessation efforts in England as part of a new national tobacco control strategy, a multi-agency report has claimed.
Experts have called for a national annual levy on tobacco companies, fresh targets such as a drop in smoking rates to 5% by 2035, a new five year government tobacco strategy for England, and an increase to the tax escalator on tobacco products to 5% above the level of inflation.
Diagnosis and treatment of cancer using genomics
The field of cancer diagnostics is in constant flux as a result of the rapid discovery of new genes associated with cancer, improvements in laboratory techniques for identifying disease causing events, and novel analytic methods that enable the integration of many different types of data. These advances have helped in the identification of novel, informative biomarkers
Genomic sequencing of only tumor tissue could be misleading in nearly half of patients, study shows
Clinicians who rely on genomic analysis of only a patient’s tumor tissue to guide cancer therapy could be misled by the presence of harmless mutations that are also present in the patient’s normal germline cells and are unrelated to the cancer, a study published in Science Translational Medicine has found
Colorectal cancer screening for older adults
In recent years evidence that the incidence of and mortality from colorectal cancer can be substantially reduced by screening has been accumulating.
Screening for colorectal cancer is now widely recommended by expert committees and is being introduced in a rapidly increasing number of countries
Vegetarians have lower risk of colon cancers, study finds
Vegetarian diets are associated with an overall lower incidence of colorectal cancers, a large prospective cohort trial has found.
The US study, published online by JAMA Internal Medicine, included 77 659 men and women who were assessed by a food frequency questionnaire and categorised into four vegetarian groups (vegan, lacto-ovo vegetarian, pesco-vegetarian, and semi-vegetarian) or a non-vegetarian group. During a mean follow-up of 7.3 years 380 cases of colon cancer and 110 cases of rectal cancer were recorded.
Study shows statin use is associated with lower risk of liver cancer
Taking a statin is associated with a near halving of the risk of liver cancer, show the results of a new study reported in the Journal of the National Cancer Institute.
Previous research has linked statins to a reduced risk of liver cancer, but much of the evidence has been from areas of the world with high rates of this type of cancer. So, researchers analysed data from the United Kingdom to investigate the effects of taking statins in a country with a relatively low incidence of liver cancer.
Acute oncology on the acute medical unit
Acute oncology on the acute medical unit
This toolkit aims to improve the care of cancer patients admitted to hospital as an emergency with medical problems due to their cancer or their treatment. It stresses the importance of patients having access to cancer specialists as soon as possible, and suggests that NHS trusts set up acute oncology services, which can work with the team in the acute medical unit to help in the management of patients with acute oncology problems.
NICE guidance – updates
Guidance by topic: the following guidance topics matching your health area preferences have been published or updated
- Acute coronary syndrome – rivaroxaban [ID532]
- Antenatal and postnatal mental health (update)
- Antenatal care
- Arrythmias – ICDs & Heart failure – cardiac resynchronisation [ID481]
- Arthritis of the hip (end stage) – hip replacement (total) and resurfacing arthroplasty (Rev TA2, TA44) [ID540]
- Asthma – diagnosis and monitoring
- Atrial fibrillation (stroke prevention) – rivaroxaban
- Atrial fibrillation – dabigatran etexilate
- BMI and waist circumference – black, Asian and minority ethnic groups
- Breast cancer (HER2 negative, oestrogen receptor positive, locally advanced or metastatic) – everolimus (with an aromatase inhibitor) [ID538]
- Colorectal cancer (metastatic) – regorafenib [ID593]
- EXOGEN ultrasound bone healing system for long bone fractures with non-union or delayed healing
- Familial breast cancer
- Gene expression profiling and expanded immunohistochemistry tests to guide the use of adjuvant chemotherapy in early breast cancer management: MammaPrint, Oncotype DX, IHC4 and Mammostrat
- Intrapartum care
- Lung cancer (non-small-cell, anaplastic lymphoma kinase fusion gene, previously treated) – crizotinib [ID499]
- Mega Soft Patient Return Electrode for use during monopolar electrosurgery
- Multiple myeloma – bortezomib (induction therapy) [ID610]
- Non Hodgkin’s lymphoma (relapsed refractory) – pixantrone monotherapy [ID414]
- Prostate cancer (hormone relapsed, metastatic) – enzalutamide (after docetaxel)
- Psoriatic arthritis (active, progressive) – ustekinumab [ID607]
- Pulmonary embolism (acute treatment, VTE prevention) – rivaroxaban [ID569]
- Pulmonary embolism and recurrent venous thromboembolism – rivaroxaban
- Self-monitoring coagulometers (CoaguChek XS system, INRatio2 PT/INR monitor and ProTime Microcoagulation system), for self-testing or self-managing coagulation status in people for whom long-term vitamin K antagonist therapy is intended.
- Systemic lupus erythematosus (autoantibody-positive) – belimumab [ID416]
- Tuberculosis (update)
- Ulcerative colitis
- WatchBP Home A for opportunistically detecting atrial fibrillation during diagnosis and monitoring of hypertension
News from Health Technology Assessments
Cancer drug can treat blindness finds HTA funded research
A cheap cancer drug is just as effective and safe in treating a common cause of loss of vision as an expensive alternative, finds research funded by the NIHR HTA Programme. [more…]
Liver function tests not efficient in identifying specific disease
Liver function tests (LFTs) result in many false positive results for each case of disease detected, and are not an efficient way to diagnose liver disease. They should be used sparingly in primary care, concludes a study funded by the NIHR HTA Programme. [more…]
Study to compare haemorrhoid treatments
A study funded by the NIHR HTA Programme could change the standard procedure for treating the painful condition of haemorrhoids. [more…]
NIHR Themed Call: Early Announcement – UPDATE
We are pleased to announce that the NIHR Antimicrobial Resistance themed call has now launched. Application forms are available from participating programmes’ websites between July and December 2013, with the HTA and EME Programmes opening first. This call is for research into the evaluation of public health measures, health care interventions and health services to reduce the development and spread of antimicrobial resistance and consequent morbidity. [more…]
The broader brief – a new way of commissioning
We are launching a new initiative to potentially commission a number of varied research proposals under the same research brief. This broader brief is in the field of MRI scanning in planning epilepsy surgery. Deadline for applications is 1pm on 29 August 2013. Full details, application forms and guidance notes are available on the HTA website. [more…]
Evidence Synthesis: one stage (full proposal)
Proposals are invited on three topics. The deadline for applications is 1pm on 29 August 2013. Full details, application forms and guidance notes are available on the HTA website. [more…]
Primary Research: two stage (outline to full proposal)
Proposals are invited on 20 topics. Deadline for applications is 1pm on 29 August 2013. Full details and guidance for applicants are available on the HTA website. [more…]
Clinical Evaluation and Trials
Applications are considered three times a year. The next cut-off deadline for proposals is 1pm on 2 September 2013. Full details, application forms and guidance notes are available on the HTA website. [more…]
Clinical Evaluation and Trials upcoming cut-off dates
6 January 2014
12 May 2014
8 September 2014
EC NHS Trust supports Lung Cancer Awareness Campaign
East Cheshire NHS Trust is supporting the Department of Health’s Lung Cancer Awareness Campaign ‘Been coughing for 3 weeks? Tell your doctor.’
Lung cancer claimed around 99 lives in Eastern Cheshire in 2012, and 148 people were diagnosed in the same time period. This makes it one of the area’s biggest causes of death.
For further information about the national lung cancer awareness campaign visit the Department of Health website http://www.dh.gov.uk/en/index.htm
Stylish headscarves for cancer patients
For cancer patients or anyone who would like to make better use of their headscarves but not sure what to do next, this website provides useful tips and great videos on how to be that little bit more stylish.
Health Matters – Tuesday 14 May
The topic this month is “East Cheshire NHS Trust – Researching Today for a Better Tomorrow”
Members of our Clinical Research Team are delivering the next Health Matters public talk on Tuesday, 14 May, 7.00-8.00pm, in the new Lecture Theatre at Macclesfield District General Hospital.
The Trust is actively involved in research in a number of key areas including cancer, dementia, Parkinson’s disease, medicines for children, cardiology, haematology, rheumatology, and stroke.
The purpose of this Health Matters talk is to demystify clinical trials, explain how they work, and look at some of the exciting research currently under way. The session will be introduced by Dr Susan Knight, and the talk will be given by our research nurses including Clare Vandor, Barbara Townley, Beverley Jones, and Joanne Shippey.
Members of staff are welcome to come along – to book your place please contact the Communications and Engagement Department on 01625 661560 or email us at ecn-tr.YourVoice@nhs.net.
Breast reconstruction presentation: Tuesday, 7th May
Mr Jalal Kokan, Consultant Oncoplastic Breast Surgeon, is giving a presentation entitled ‘Breast Reconstruction’ on 7th May 2013, 5.30 – 7pm.
The free event is being held in the Macmillan Cancer Resource Centre, Macclesfield District General Hospital. Breast care nurses will also be present to answer any questions, and light refreshments will be available.
For more information or to book your place, please call 01625 663079 or email Nicola.email@example.com
Kings Fund: Statistics for March/April
- Critical care bed capacity and cancelled operations: monthly situation reports – March 2013
- Acute and non-acute delayed transfers of care: monthly situation reports – March 2013
- A&E weekly data – week ending 21 April 2013
- Provisional monthly hospital episode statistics for admitted patient care, outpatients and accident and emergency data – April 2012 to December 2012
- Mental health bulletin: annual report from MHMDS returns – England 2011/12, further analysis and organisation-level data
- Carers UK – carer support survey
- NHS spend on medicines – ABPI
- Care home business failures
- Department of Health complaints handling performance
- Data on cancer research funding
WebWatch: Cancer Commons
Extract from website at: http://www.cancercommons.org/researchers-clinicians/
CANCER COMMONS “is an open science initiative linking patients, physicians and scientists in rapid learning communities. Our mission is to ensure that patients are treated in accord with the latest knowledge on targeted- and immunotherapies, and to continually update that knowledge based on each patient’s response.”
Advisory boards, comprising leading physicians and scientists in each cancer, curate the molecular model that identifies the most relevant tests, treatments, and trials for each molecular sub type of that cancer, based on the best current knowledge.
Test and Treat
Patients and physicians access knowledge derived from the model, as soon as it’s deemed actionable, through alerts, notifications, news, and applications that inform testing and treatment decisions.
Report and Analyze
Physicians, researchers, and patients report clinical observations and outcomes and new data are analyzed in our Rapid Learning Communities by collaborative, interinstitutional teams to validate, refute, and amplify the current model’s knowledge and hypotheses.
The advisory boards review these results and update the framework in real time.
News from NICE
NICE recommends blood pressure device that can help prevent strokes
A new device that allows GPs and practice nurses to detect pulse irregularities and pick up cases of atrial fibrillation whilst measuring blood pressure has been recommended by NICE. Atrial fibrillation (AF) causes the heart to beat with an irregular rhythm. It can be difficult to detect and subsequently diagnose as it is often asymptomatic and can be intermittent.
People with AF are at increased risk of developing blood clots and subsequent stroke, with 423,000 people aged 65 and over expected to have AF, of whom some will be will living with the condition yet are undiagnosed.
In its medical technology guidance on WatchBP Home A, NICE says the device reliably detects AF and may increase the rate of detection when used in primary care. This will consequently allow for preventative treatment to be given and to reduce the incidence of AF-related stroke.
|Statement of collaboration between NICE and Public Heath England
NICE and Public Health England agreed to collaborate on future work.
February 8, 2013
|Dementia, stroke and cancer among potential indicators for latest CCG Outcomes Indicator Set
Dementia, stroke, cancer, and end-of-life care are among 32 new indicators put forward for inclusion in the Clinical Commissioning Group Outcomes Indicator Set (CCG OIS).
February 4, 2013
|Have your say on NICE’s social care work
The Department of Health has launched a 12 week consultation to gather views on the topics for NICE’s new quality standards and guidance for social care.
February 1, 2013