The long wait for a breakthrough in chronic fatigue syndrome

Click for article

Click for article

There hasn’t been much good news for patients with the prevalent but enigmatic disorder chronic fatigue syndrome (also referred to as myalgic encephalomyelitis). Over decades, research into the pathophysiology has failed to find convincing evidence of either persistent infection or immunological, endocrine, or metabolic change, and has rejected simplistic notions of depression (typical or atypical) or primary sleep disorder. Several notable “breakthroughs” have failed independent replication.

The most noteworthy is the recent rise and fall of xenotropic murine leukaemia virus related virus (XMRV) as the cause, which was ultimately established as a murine DNA laboratory contaminant.

Similarly, an exhaustive array of randomised controlled trials seeking curative outcomes from antiviral, immunological, hormonal, antidepressant, and many other therapies have failed to show any benefit over placebo, or failed the replication test.

US panel proposes new name and diagnostic criteria for chronic fatigue syndrome

The condition known as myalgic encephalitis (ME) or chronic fatigue syndrome (CFS) thebmj_logois a serious, chronic multisystem disease that can cause significant impairment and disability, an expert panel convened by the US Institute of Medicine has concluded in a new report. The committee proposed a new set of diagnostic criteria and a new name for the condition: systemic exertion intolerance disease (SEID).