What is the future of hospitals? Mark Newbold
|
What to do about unsafe medicines? Gillian J Buckley, Jim E Riviere, and Lawrence O Gostin
|
Descriptions of non-pharmacological interventions in clinical trials A Cook, L Douet, and Isabelle Boutron
|
The word “cancer”: how language can corrupt thought BK Dunn, Sudhir Srivastava, and Barnett S Kramer
|
Secondary prevention of venous thromboembolism Sam Schulman and James Douketis
|
clinical_trials
BMJ topics: August 2013
Here’s a selection of content from this month’s BMJ – click on this link if you want to read the full issue.
Feature |
Patient information leaflets: “a stupid system” Margaret McCartney
|
The growth of medical marijuana Owen Dyer
|
News![]() |
GPs taking on out of hours work face higher indemnity fees Gareth Iacobucci
|
Don’t call low risk lesions cancer, experts say Michael McCarthy
|
Editorials |
Physician Payment Sunshine Act José G Merino
|
The Liverpool care pathway: a cautionary tale Katherine E Sleeman and Emily Collis
|
Medical savings accounts: Singapore’s non-solution to healthcare costs Martin McKee and Reinhard Busse
|
India’s new policy to protect research participants Jeremy Sugarman, Anant Bhan et al
|
Government’s plans for universal health checks for people aged 40-75 Felicity Goodyear-Smith
|
Leading healthcare in London: time for a radical response? Naomi Fulop and Rosalind Raine
|
European Radiology, July 2012; Imaging vascular function for early stage clinical trials …
Imaging vascular function for early stage clinical trials using dynamic contrast-enhanced magnetic resonance imaging
Citation: European Radiology, July 2012, vol./is. 22/7(1451-1464), 0938-7994;1432-1084 (July 2012)
Author(s): Leach M.O.; Morgan B.; Tofts P.S.; Buckley D.L.; Huang W.; Horsfield M.A.; Chenevert T.L.; Collins D.J.; Jackson A.; Lomas D.; Whitcher B.; Clarke L.; Plummer R.; Judson I.; Jones R.; Alonzi R.; Brunner T.; Koh D.M.; Murphy P.; Waterton J.C.; Parker G.; Graves M.J.; Scheenen T.W.J.; Redpath T.W.; Orton M.; Karczmar G.; Huisman H.; Barentsz J.; Padhani A.
Abstract: Many therapeutic approaches to cancer affect the tumour vasculature, either indirectly or as a direct target. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has become an important means of investigating this action, both pre-clinically and in early stage clinical trials. For such trials, it is essential that the measurement process (i.e. image acquisition and analysis) can be performed effectively and with consistency among contributing centres. As the technique continues to develop in order to provide potential improvements in sensitivity and physiological relevance, there is considerable scope for between-centre variation in techniques. A workshop was convened by the Imaging Committee of the Experimental Cancer Medicine Centres (ECMC) to review the current status of DCEMRI and to provide recommendations on how the technique can best be used for early stage trials. This review and the consequent recommendations are summarised here. Key Points Tumour vascular function is key to tumour development and treatment Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can assess tumour vascular function Thus DCE-MRI with pharmacokinetic models can assess novel treatments Many recent developments are advancing the accuracy of and information from DCE-MRI Establishing common methodology across multiple centres is challenging and requires accepted guidelines.
European Society of Radiology 2012.
Publication Type: Journal: Article
Source: EMBASE