Sepsis-associated mortality in England

: an analysis of multiple cause of death data from 2001 to 2010

Duncan McPherson1 Clare Griffiths  Matthew Williams  Allan Baker
Ed Klodawski   Bobbie Jacobson   Liam Donaldson

To quantify mortality associated with sepsis in the whole population of England.

Design: Descriptive statistics of multiple cause of death data.

Setting: England between 2001 and 2010.

Participants: All people whose death was registered in England between 2001 and 2010 and whose certificate contained a sepsis-associated International Classification of Diseases, 10th Revision (ICD-10) code.

Data sources: Multiple cause of death data extracted from Office for National Statistics mortality database.

Statistical methods: Age-specific and sex-specific death rates and direct age-standardised death rates.

Results: In 2010, 5.1% of deaths in England were definitely associated with sepsis. Adding those that may be associated with sepsis increases this figure to 7.7% of all deaths. Only 8.6% of deaths definitely associated with sepsis in 2010 had a sepsis-related condition as the underlying cause of death. 99% of deaths definitely associated with sepsis have one of the three ICD-10 codes—A40, A41 and P36—in at least one position on the death certificate. 7% of deaths definitely associated with sepsis in 2001–2010 did not occur in hospital.

Conclusions: Sepsis is a major public health problem in England. In attempting to tackle the problem of sepsis, it is not sufficient to rely on hospital-based statistics, or methods of intervention, alone. A robust estimate of the burden of sepsis-associated mortality in England can be made by identifying deaths with one of the three ICD-10 codes in multiple cause of death data. These three codes could be used for future monitoring of the burden of sepsis-associated mortality.

King’s Fund Statistics

Cancer services coming of age

Learning from the improving cancer treatment assessment and support for older people project
This report summarises a series of pilots that tested whether appropriate assessment of older cancer patients would result in improved access to appropriate cancer treatment, based on need and not age. It also tested whether action, as a result of an age appropriate assessment, improved the scope for older people to benefit from treatment.



Cancer Statistics from The King’s Fund

Clinical Evidence Update

In addition to regular updates to systematic reviews and guidelines, the new Clinical Evidence website includes additional educational and practical resources.  Discover more about evidence based medicine.

Estimates of prevalence of this condition vary widely depending on population and study recruitment criteria. What is clear, though, is that the condition is common, and that women with severe prolapse can suffer unpleasant and debilitating symptoms. Our latest update covers important new evidence on hormone treatments and surgical options.

Visit the Clinical Evidence website to see the full review.


For more information on all the above systematic reviews, visit the Clinical Evidence website.

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